The GastroPlus® Additional Dosage Routes Seminar Series

 

June 1 - 5, 2020
8:00 - 9:00 AM PST

Schedule:

Mon. June 1st – Pulmonary & Oral Cavity with John DiBella

Tues. June 2nd – Transdermal with Jessica Spires

Weds. June 3rd – Intramuscular & Subcutaneous with Viera Lukacova

Thurs. June 4th – Ocular with Maxime Le Merdy

Fri. June 5th – Ask Us Anything panel discussion with Viera Lukacova, Michael Bolger, Sandra Suarez- Sharp, Grace Fraczkiewicz , Jessica Spires, Max Le Merdy, Jim Mullin, Ke Szeto

Monday, June 1st – Pulmonary & Oral Cavity

 

The Pulmonary Compartmental Absorption & Transit (PCAT™) model represents the lung/nose as a collection of the following compartments: an optional nose (containing the anterior nasal passages), extra-thoracic (naso- and oro-pharynx and the larynx), thoracic (trachea and bronchi), bronchiolar (bronchioles and terminal bronchioles) and alveolar-interstitial (respiratory bronchioles, alveolar ducts and sacs and interstitial connective tissue).

 

The Oral Cavity Compartmental Absorption & Transit (OCCAT™) model represents the oral cavity (mouth) as a collection of the following compartments: buccal, gingival, palate, top of the tongue, bottom of the tongue, and mouth floor.

 

Tuesday, June 2nd – Transdermal

 

The Transdermal Compartmental Absorption & Transit (TCAT™) model represents the skin as a collection of the following compartments: stratum corneum, viable epidermis, dermis, subcutaneous tissue, sebum, hair lipid, and hair core.

Wednesday, June 3rd – Intramuscular

 

The intramuscular (IM) drug delivery model represents the site of injection as a single compartment. Within this compartment, drug can be bound, and local clearance can take place. Drug can also be transported into the lymph or systemic circulation. 

 

GastroPlus now provides two intramuscular (IM) dosage forms, both of which assume that drug is injected into the muscle tissue. One of these is an immediate release (IR) dosage form, with the other treated as controlled release (CR).

 

Poster
Journal Article

Thursday, June 4th – Ocular

 

The Ocular Compartmental Absorption & Transit (OCAT™) model represents the eye as a collection of the following compartments: pre-cornea, cornea, conjunctiva, aqueous humor, anterior sclera, posterior sclera, iris-ciliary body, choroid-RPE (a combination of choroid and the retinal pigment epithelium), retina, anterior and posterior vitreous humor.

 

Journal Article 

Journal Article

Slideshow Presentation

Friday, June 5th – Ask Us Anything panel discussion (all instructors)

 

All of the ADR models were all developed in collaboration with top pharmaceutical companies and/or the U.S. FDA.

Prerequisite:

· Familiarity with setting up and running basic GastroPlus simulations,

· including database & support file structures,

· basic inputs for physicochemical & pharmacokinetic parameters,

· and basic physiology options for human & animal simulations